Effects of alcohol on the symptoms of gouty arthritis and taxonomic structure of gut microbiota in C57BL/6 mice

Gout is an acute arthritis caused by the elevated levels of serum uric acid (UA), and its prevalence has been rapidly increasing. Alcohol abuse could lead to a series health problems. Multiple pieces evidence suggest that alcohol intake affects development progression gout, while gut microbiota plays important role in gout long-term consumption affect stability microbiota. This study aimed explore effects at different concentrations on gouty based We investigated mouse models established injection monosodium urate (MSU) crystals into C57BL/6 mice. The results indicated high-alcohol not only exacerbated joint swelling pain, increased UA, tumor necrosis factor-α (TNF-α), interleukin-1β (IL-1β), interleukin-6 (IL-6), but also showed dramatic composition structure Two key microorganisms, Parasutterella Alistipes , aggravate symptoms through lipopolysaccharide biosynthesis, riboflavin metabolism, phenylalanine arginine proline metabolisms. In conclusion, our suggested high-concentrations altered mice induced MSU crystals, which exacerbate enhancing pro-inflammatory pathways.